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this incorrect response doesnt belongs to the sending smtp, but the receipient.

this looks like some stale dns cache at the destination. the ip doesnt looks listed from your URL.

Filezille does support drag & drop but only within its Window

I think you are looking for "webdrive"(www.webdrive.com) kinda software. They probably do not support permissions on windows. That however can be done with cuteftp.