Error: relaying denied from your location

I get the following when I try to email to a particular domain. And depending on whether SPF is on, off, and what settings actually result in other errors. Could someone shed some light on this.

Thanks

Code:
Hi. This is the qmail-send program at @.
I'm afraid I wasn't able to deliver your message to the following addresses.
This is a permanent error; I've given up. Sorry it didn't work out.

<support@????.com>:
64.202.166.12 does not like recipient.
Remote host said: 553 sorry, relaying denied from your location [64.187.103.252] (#5.7.1) Giving up on 64.202.166.12.

--- Enclosed are the original headers of the message.
 
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