WordPress Shopping Carts

I have a potenetial customer with a WordPress site that will want to be adding a shopping cart. Anyone here have any recommendations on WordPress shopping carts? Anything special I'll need to know or do when I setup WordPress on the account to make the shopping cart setup easier/better?
 
First request I have ever seen for wordpress shopping carts, blog shopping? :D maybe a new trend I have not caught on with.
 
Well, it seems what were once meant to be CMS systems for blogs have turned into general website CMS, what with all the templates, plug-ins, etc. available.
 
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